Poly-L-ornithine
Poly-L-ornithine for nucleic acid trasfection,coatings and biomedical aplications.
Available in research and GMP grades with custom modifications
About the Poly-L-ornithine
Poly-L-Ornithine is a synthetic cationic polyamino acid widely used in gene delivery, biomaterials and advanced drug delivery systems. Its strong positive charge provides high affinity for negatively charged biomolecules, particularly nucleic acids, making it an effective polymer for non-viral delivery applications. Curapath’s proprietary synthesis technology enables the production of Poly-L-Ornithine with tailored molecular weights and low polydispersity.
The multiple primary amine groups along the polymer backbone enable efficient nucleic acid complexation while supporting surface functionalization and coating applications. Poly-L-Ornithine enhances cell attachment on a wide range of substrates and has been successfully applied to stem cells, immune cells and other advanced cell models. It has also been shown to improve drug release from nanoparticle-based delivery systems.
Poly-L-Ornithine is widely used in gene delivery, nanoparticle formulation, cell-interactive coatings and advanced biomaterials, supporting the development of innovative drug delivery technologies.
Uses of Poly-L-ornithine
Gene Delivery
Poly-L-ornithineforms stable electrostatic complexes with DNA, mRNA, siRNA and other nucleic acids, enabling efficient intracellular delivery. Its high cationic charge makes it an excellent polymer for non‑viral gene‑delivery systems.
Nanoparticle Drug Delivery
Poly-L-Ornithine is used in nanoparticle-based drug delivery systems to improve payload encapsulation, stability and controlled drug release. Its tunable molecular weight and strong electrostatic interactions make it a versatile polymer for next-generation nanomedicine platforms.
Cell & Surface Coatings
Poly-L-Ornithine is widely used as a surface coating to enhance cell attachment and growth on a variety of biomaterials and culture substrates. These properties support applications ranging from advanced cell models to regenerative medicine and biomedical research.
Biomaterials & Medical Devices
Poly-L-Ornithine enables the functionalization of biomaterials, hydrogels and medical device surfaces through its reactive primary amine groups. Its biocompatibility and versatile chemistry make it an attractive polymer for tissue engineering and advanced biomedical devices.
Formats Available
Degree of polymerization
In curapath we have a deep control over the polymerization, being able to achive a wide range of molecular weights, our standar offer includes :
- Polyornithine-25
- Polyornithine-50
- Polyornithine-75
- Polyornithine-100
- Polyornithine-200
- Custom formats
Quality Levels
R&D Grade Polyornithine
Ideal for early-stage research, formulation development and proof-of-concept studies. Manufactured under rigorous quality standards with comprehensive analytical characterization for reproducible research.
Medical Device Grade Polyornithine
Designed to support medical device applications with enhanced quality documentation, traceability and regulatory support. Suitable for biomaterials, coatings and implantable device development.
GMP Grade Polyornithine
Manufactured under GMP conditions for clinical and commercial applications. Supported by validated quality systems, batch traceability, regulatory documentation and scalable production.
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Frequently asked questions (FAQs)
What is Curapath
Curapath is a European Contract Development and Manufacturing Organization (CDMO) specialized in non-viral drug delivery systems. We support biotech and pharmaceutical companies from early development through GMP-ready and commercial manufacturing, combining proprietary delivery components, in-house technologies, and deep expertise in complex formulation and CMC development.
What are the advantages of Poly-L-Ornithine over other cationic polymers?
Poly-L-Ornithine combines strong nucleic acid binding, excellent surface functionalization capabilities and tunable polymer properties. Its versatility makes it suitable for gene delivery, nanoparticle formulation and biomaterial applications across a wide range of therapeutic platforms.
Can Curapath customize Poly-L-Ornithine?
Yes. Curapath can synthesize Poly-L-Ornithine with tailored molecular weights and low polydispersity. Additional functionalization and custom polymer development can also be performed to meet specific application requirements.
Is GMP-grade Poly-L-Ornithine available?
Yes. Curapath offers Poly-L-Ornithine in research and GMP grades, supported by scalable manufacturing, robust quality systems and regulatory documentation for pharmaceutical development.
Why choose Curapath as your Poly-L-Ornithine supplier?
Curapath combines proprietary polymer synthesis, custom functionalization and GMP manufacturing under one CDMO. We produce Poly-L-Ornithine with tailored molecular weights, low polydispersity and scalable manufacturing to support research, clinical development and commercial applications.
