Explore Curapath's polymer and lipid platforms for drug delivery and biomanufacturing.
Linear Polyethylenimine (PEI)
Linear PEI for transfection, viral vector production and recombinant protein expression. Available in R&D and GMP grades, with scalable manufacturing and powder or solution formats.

About Curapath® PEI
Curapath® PEI (linear polyethylenimine Hydrochloride, MW 20,000 Da) forms stable complexes with DNA, supporting efficient nucleic acid delivery in applications ranging from in vitro cell transfection to viral vector production and recombinant protein expression.
Available as a dry form or solution in R&D and GMP grades, Curapath PEI® supports the transition from process development to clinical and commercial manufacturing. Its optimized formulation enables high-titer vector and recombinant protein production while maintaining cell viability, offering a reliable and scalable alternative to conventional PEI-based transfection reagents.
Commonly Used For
Linear PEI is a versatile transfection reagent widely used in research, process development, and bioproduction workflows. It is particularly valuable for plasmid delivery in mammalian cells, supporting both exploratory R&D and scalable upstream applications.
Transient Expression and Stable Cell Line Development
PEI is commonly used for transient transfection in mammalian cells and for the generation of stable producer cell lines, enabling efficient gene delivery during early discovery and cell line development workflows.
Co-Transfection and Sequential Transfection Workflows
Its flexibility makes PEI suitable for co-transfection strategies and sequential transfection protocols, helping researchers introduce multiple plasmids or optimize multistep expression workflows in vitro.
AAV and Lentiviral Vector Production
PEI is widely adopted for plasmid delivery during AAV and lentiviral vector production, supporting efficient transfection of producer cells in workflows used for gene therapy and advanced therapy development.
Recombinant Protein and Monoclonal Antibody (mAb) Expression
PEI is frequently used in recombinant protein and monoclonal antibody expression systems, offering a practical and scalable option for upstream transfection in biologics development and production.
Curapath® PEI Product Overview
Different Formats
Curapath has developed a proprietary, rapid and scalable process to manufacture linear PEI for applications from early research through clinical and commercial manufacturing.
Available in dry and solution formats, and in R&D and GMP grades, Curapath PEI® supports a streamlined transition to commercial manufacturing.

Product Performance
In the comparative studies shown, Curapath PEI® demonstrated transfection performance comparable to or better than leading benchmark reagents under the conditions tested.
Combined with an efficient and scalable manufacturing process, it offers a cost-effective supply solution as production requirements grow.

Technical Specifications: Dry Format
Example of certificate of analysis (CoA) of dry PEI (R&D grade).
This format is suitable for teams looking for a powdered linear PEI presentation with defined analytical specifications and supporting quality documentation for research workflows.

Technical Specifications: Solution Format
Example of certificate of analysis (CoA) of solution PEI (R&D grade).
This format supports workflows requiring ready-to-use liquid PEI, with quality attributes and analytical parameters documented to facilitate evaluation, reproducibility, and process development.

Request Curapath® PEI
Select the Curapath PEI® format that best fits your application and submit the corresponding product request. Our team will review your requirements and contact you directly.
Request Dry Curapath® PEI
Complete the form below to request Curapath PEI® in dry format. Our team will review your application, grade and supply requirements.
Request Curapath® PEI Solution
Complete the form below to request Curapath PEI® in solution format. Our team will review your application, grade and supply requirements.