Curapath and Cayman Chemical Partner to Expand Access to PEG-Free Shielding Lipids for Advanced LNP Formulations

VALENCIA, SPAIN, SEPTEMBER 2, 2025

At Curapath, our mission has always been to push the boundaries of non-viral drug delivery. Today, we are proud to announce a strategic partnership with Cayman Chemical that will make our proprietary PEG-free shielding lipids more accessible to researchers worldwide.

Through Cayman’s extensive global distribution network, scientists will now be able to source Curapath’s polysarcosine (pSar) and polyaminoacid-based shielding lipids for use in lipid nanoparticle (LNP) development, supporting applications in gene therapy, mRNA vaccines, and biologic drug delivery. Additional high-quality polymers, including poly(lysine) and poly(glutamic acid), as well as cationic polymers optimized for gene transfection, will also become widely available.

Developed and manufactured at our headquarters in Valencia, Spain, Curapath’s pSar lipids provide a non-toxic, non-immunogenic, and biodegradable alternative to traditional PEGylated lipids, without compromising efficacy in LNP formulations.

PEGylated lipids have long been used to shield LNPs from immune detection, but their association with immunogenicity and adverse reactions is driving the search for better solutions. Our PEG-free polymers address these challenges head-on, giving researchers a safe and effective option to advance next-generation therapies.

At Curapath, we believe this collaboration is more than just product availability — it’s about accelerating innovation. By combining Cayman’s global reach with our science-driven innovation and GMP manufacturing expertise, we are helping researchers translate their discoveries into real therapeutic impact.

Learn more about the partnership here: www.caymanchem.com/curapath

About Curapath

Curapath is a science-driven CDMO specializing in the design, development, and GMP manufacturing of advanced drug delivery systems. We support biopharma companies from early R&D through to commercial production, enabling innovation across every stage. Our expertise lies in non-viral gene delivery, offering polymer and lipid-based nanoparticles tailored for a wide variety of payloads. From excipient synthesis to drug product formulation, our flexible service model and proprietary technologies ensure seamless development.

About Cayman Chemical

Cayman Chemical helps make research possible by providing products and services to scientists worldwide. Their portfolio includes biochemicals, assay kits, antibodies, and proteins, empowering researchers to understand biological mechanisms and develop new therapies. Cayman’s scientists bring expertise in lipid chemistry, synthesis, purification, and characterization, and operate across facilities in Ann Arbor, Michigan, and Neratovice, Czech Republic.

Learn more at www.caymanchem.com.

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